Heavy habitual use of marijuana can lead to "blue sclera". In some cases the prolonged use of marijuana leads to dark blue spots on the sclera as well. Use of over the counter eye medications to "clear" or "wash" the eyes will not have have an effect on blue sclera. Only after several days of non use of maruijuana will blue sclera start to go away.
Points to Remember: Blue sclerae characteristically are associated with heritable disorders of connective tissue. They appear chiefly in osteogenesis imperfecta and to a lesser extent in pseudoxanthoma elasticum, Ehlers-Danlos syndrome, and Marfan's disease. Rarely, they are seen in patients with iron deficiency, rheumatoid arthritis, or myasthenia gravis. The blue discoloration occurs when thinning of the sclera allows the underlying choroid to become visible.
The patients presented here had osteogenesis imperfecta, an autosomal dominant disorder marked by defective formation of collagen. Its cardinal manifestations are blue sclerae, fragile bones, and deafness. Two types exist—congenita and tarda. The former is clinically severe, and survival beyond childhood is uncommon. The latter, however, has a much milder course, and such patients may live to an advanced age.
